PIPELINE

We are focused on developing transformative diagnostic solutions and breakthrough therapies for a range of serious, often fatal diseases by leveraging our unique expertise in Nanobiotechnology.

OncoSense

OncoSense is a revolutionary next-generation MRI Contrast Media containing superparamagnetic iron oxide nanoparticles. OncoSense is most sensitive to the changes in molecular information rather than anatomic changes, which helps in the early detection of hidden/occult micrometastasis. It uses triple targeting technology which includes receptor targeting & endocytosis along with Endothelial Leakiness Effect and Enhanced Permeability and Retention Effect (EPR). OncoSense can easily cross the blood-brain barrier more effectively than any other MRI contrast agent available currently in the market. The time it takes to complete diagnostic tests will be reduced by the usage of OncoSense as the contrast enhancement media.

OncoSense-TT

TT version of OncoSense is a preclinical stage targeted therapy cum drug delivery vehicle which can carry multiple payloads of drugs into a cancer cell. Tumour specific delivery of therapeutics will very much increase the efficacy of the treatment while decreasing untoward side effects, thus widening the therapeutic window. OncoSense-TT can also deliver siRNAs along with anticancer drugs into the core of a cancer cell, terminating even the most evolved drug-resistant metastatic cancer cells.

 

MikróSense

Antimicrobial resistance is recognized as one of the greatest threats to human health worldwide. New resistance mechanisms are emerging and spreading globally, threatening our ability to treat common infectious diseases. MikróSense is a biosynthesized silver nanoparticles based therapy system who's action involves a complex mechanism in which more than one factor can act simultaneously to contribute to the overall effect. We have developed a Carbenicillin-Silver Nanoformulation which is highly toxic to wide varieties of gram-negative and gram-positive bacteria. The repeated exposure of bacterial cultures with Car-AgNps does not show any emergence of resistance. Thus these Car-AgNps can be used as drugs against resistant bacteria as these are non-toxic to human cells as shown by our multiple MTT and XTT assays. The nanoparticles were effective at inhibiting bacteria in both the nanomolar & micromolar range.

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Thiruvananthapuram, Kerala, India

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